Zeco AHU
Zeco AHU
Zeco air conditioners are of high quality with highly efficient and durable. Some of their best features are:Safety of loop diuretics in patients with acute congestive heart failure.
Loop diuretics have been used in patients with acute congestive heart failure (CHF) for decades. The safety of this class of diuretics has been questioned. The objective of this review was to assess the safety of loop diuretics in patients with acute CHF. We searched the Cochrane Library, MEDLINE, EMBASE, International Pharmaceutical Abstracts, and Science Citation Index (from 1950 to September 2005) for randomized controlled trials comparing loop diuretics (loop diuretics only or loop diuretics combined with an alkalinizing agent) and placebo or active comparators in patients with acute CHF. Two reviewers independently assessed the eligibility of studies and extracted data. We included 27 randomized controlled trials with 2519 patients who received loop diuretics (28% loop diuretics only, 37% loop diuretics with an alkalinizing agent, and 35% loop diuretics with a potassium-binding agent). Most patients were of New York Heart Association functional class II or III (88%) and were receiving digoxin (74%). Loop diuretics were associated with increases in creatinine, potassium, glucose, and hyperkalemia (≥6.0 mmol/L) and a decrease in chloride in patients who received the diuretics. The number needed to harm with loop diuretics was 14, and the number needed to treat with a cardiotoxic drug was 32 to achieve a 10% increase in mortality or a 50% reduction in event-free survival (5.9% at one year and 10.3% at two years). The number needed to treat with a cardiotoxic drug to achieve a 10% increase in mortality or a 50% reduction in event-free survival (13.5) was greater with loop diuretics plus an alkalinizing agent than loop diuretics alone. Loop diuretics have a significant risk of fluid retention, hyperkalemia, and possibly cardiotoxicity. Only a small increase in adverse events might be acceptable if no more harm were done than good. The results of this review do not support the use of loop diuretics alone in patients with acute CHF.Q:
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